Assessment of Plasma Antioxidant Status in Hemodialysis Patients
Mehri Kadkhodaee, Mohammad Hemmati, Maryam Zahmatkesh, Rana Ghaznavi,
Fatemeh Mirershadi, Mitra Mahdavi-Mazde, and Behjat Seifi
Department of Physiology, School of Medicine, Tehran University of
Medical Sciences, Tehran, Iran
Correspondence to  Dr Mehri Kadkhodaee, Department of Physiology,
School of Medicine, Tehran University of Medical Sciences, Enghelab
Street, Poursina Avenue, 141556447 Tehran, Iran. Email:
kadkh...@tums.ac.ir
Copyright Journal compilation © 2008 International Society for
Apheresis
KEYWORDS
Antioxidants • Hemodialysis • Oxidative stress
ABSTRACT
Abstract:
The risk of atherosclerosis and cancer is high in patients on
hemodialysis.
A breakdown in the natural balance between the activity of the body's
antioxidant system and the production of oxidizing agents is suggested
to be involved.
To investigate the oxidative stress status in Iranian hemodialytic
patients, in this study we evaluated plasma vitamin E, malondialdehyde
(MDA), reduced glutathione (GSH), and ferric reducing antioxidant
power (FRAP) levels in these patients. Twenty-four hemodialytic
patients and 24 control subjects (age and sex matched) were included
in this study.
Each patient was under dialysis, three times per week, four hours in
each session.
Before and after dialysis, blood was taken for biochemical
measurements as well as oxidative stress tests.
There was a significant decrease in FRAP and GSH levels after dialysis
comparing to before treatment levels.
MDA was increased by dialysis and vitamin E levels were less in
dialytic patients, both before and after treatment, compared to
controls.
This study indicates that there is a significant level of oxidative
stress in chronic renal patients and this stress is augmented by
dialysis.
Antioxidant therapy could be considered in these patients.

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Received January 2007; revised June 2007.

DIGITAL OBJECT IDENTIFIER (DOI)
10.1111/j.1744-9987.2008.00561.x About DOI

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